Sustained local delivery of high-concentration vancomycin from a hybrid biodegradable antibiotic-eluting nanofiber-loaded endovascular prosthesis for mycotic aortic aneurysm: in vitro and in vivo studies

K.S. Liu, C.H. Chen, M. Liu, Y.Y. Tseng,

Journal of Vascular Surgery, (provisionally accepted) (2017)

Background: Endovascular repair for mycotic aortic aneurysm (MAA) is a less invasive alternative to open surgery, although the placement of a stent graft in an infected environment remains controversial. In this study, we developed

hybrid biodegradable, vancomycin-eluting, nanofiber-loaded endovascular prostheses and evaluated antibiotic release from the endovascular prostheses both in vitro and in vivo.

Conclusions: The proposed biodegradable vancomycin-eluting nanofibers significantly contribute to the achievement of local and sustainable delivery of antibiotics to the aneurysm sac and the aortic wall, and these nanofibers may have therapeutic applications for MAAs. (J Vasc Surg 2018;68:597-606.)